Otay Mesa Vacation Rentals

Compare Vacation Rentals & Rent By Owner Homes in Otay Mesa, San Diego, California, USA

|
10.0 (2 Reviews)
5 Bedrooms 12 Guests
7.8 (1409 Reviews)
1 Bedroom 2 Guests
|
10.0 (1 Review)
5 Bedrooms 12 Guests
7.2 (1001 Reviews)
1 Bedroom 2 Guests
|
9.0 (1 Review)
5 Bedrooms 16 Guests
From US $331 per night
New
4 Bedrooms 10 Guests
|
7.0 (389 Reviews)
71 Bedrooms 19 Guests
9.8 (24 Reviews)
5 Bedrooms 12 Guests
9.8 (6 Reviews)
3 Bedrooms 8 Guests
9.4 (42 Reviews)
5 Bedrooms 12 Guests
4.8 (6 Reviews)
1 Bedroom 6 Guests
From US $219 per night
New
4 Bedrooms 8 Guests
9.0 (25 Reviews)
5 Bedrooms 16 Guests
8.0 (4 Reviews)
6 Bedrooms 16 Guests

About Otay Mesa Vacation Rentals

With more than 30 Otay Mesa vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Rent By Owner Homes (RBOs) and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at an RBO property in Otay Mesa.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With RentByOwner Otay Mesa, you have the flexibility of comparing different options of various deals with a single click. Looking for an RBO with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner (RBOs), and other popular Airbnb-style properties in Otay Mesa. Places to stay near Otay Mesa are 1146.14 ft² on average, with prices averaging US $360 a night.

RentByOwner makes it easy and safe to find and compare vacation rentals in Otay Mesa with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Otay Mesa Vacation Rental Frequently Asked Questions

What are the top vacation rentals in Otay Mesa?

How many Rentbyowner vacation rentals are available in Otay Mesa?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 30 in the Otay Mesa area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Otay Mesa. 

Nearby Neighborhood (3)

Neighborhood Property Count
Otay Ranch Vacation Rentals in San Diego, California 59
Ocean View Hills Vacation Rentals in San Diego, California 110
Princess Park In California Terraces Vacation Rentals in San Diego, California 83